What Causes Abnormal Pap Tests - Arizona Gynecological Consultants

What Causes Abnormal Pap Tests?

All women will eventually undergo a Pap test, or Pap smear test, as a regular part of their routine medical examinations. Most women begin yearly Pap smear tests at age 21 or within three years of becoming sexually active. This procedure is one of the best methods for detecting signs of cervical cancer as early as possible, but it can detect other medical conditions as well.

During a Pap smear test, the gynecologist uses a special medical swab to remove a cell sample from the cervix, the lower opening of the uterus that connects to the vagina. Most women barely feel the test, but some experience mild cramping and discomfort as the gynecologist scrapes the cervix.

Reasons for Abnormal Pap Test Results

Some abnormal Pap smear test results happen because of relatively innocuous issues like yeast infections, bacterial infections or immune system irregularities. Smoking can cause abnormal cervical cell changes as well. Other times, an abnormal result can indicate a more serious infection.

Most abnormal Pap test results are the result of some types of the human papillomavirus (HPV). This sexually transmitted disease can linger dormant in a woman’s system for years before manifesting noticeable symptoms.

A woman may have HPV for years without ever noticing anything is wrong. The cell changes that occur from some types of HPV will fade on their own over time. Although, other types of HPV can lead to cervical cancer.

Limiting Your Risk of Contracting HPV

Since HPV is a sexually transmitted disease, maintaining responsible sexual habits and practicing safe sex are two of the best ways of protecting yourself from the virus and other sexually transmitted infections.

Women who have sex with multiple partners, have sex without condoms, or have sex with one partner who also has other partners are at a higher risk of contracting HPV than women in monogamous sexual relationships.

Symptoms of Abnormal Pap Tests

A Pap smear test detects changes in cervical cells, but these changes do not entail symptoms on their own. Depending on the type of change occurring, a woman may experience a variety of possible symptoms.

Different sexually transmitted diseases cause their own set of symptoms, such as:

  • Abnormal vaginal discharge
  • Lumps
  • Blisters
  • Sores
  • Warts on the genital area
  • A burning sensation or discomfort during urination or intercourse
  • Rashes

What Do My Test Results Mean?

Gynecologists deliver Pap smear test results with different classifications based on the doctor’s findings. A result of “normal” indicates that the sample cells are healthy, and that there are no irregularities in the patient’s cervix.

An “unsatisfactory” result indicates a problem with the test sample. If the lab technician cannot properly read a sample, the patient will have to retake the examination.

Another possible outcome is “benign changes,” or a relatively normal result with some minor irregularities. These benign changes can include inflammation of the cervical cells, and the gynecologist will likely recommend further tests or treatment for the cause of the inflammation.

Finally, some Pap smear tests will lead to “ASCUS” results, or “atypical squamous cells of undetermined significance.” These results break down further into more specific categories.

Possible Results and Follow-Up Tests

After an ASCUS reading, the gynecologist will sometimes recommend another Pap test later or send the patient for additional screenings. Women under the age of 24 who receive abnormal Pap test results typically receive one of the following diagnoses:


Women who receive this diagnosis have cervical cells that display signs of HPV. The doctor will recommend a colposcopy as a follow-up exam. A colposcopy is a more in-depth inspection of the vulva, vagina, cervix and uterus using cameras and illumination devices to spot signs of infection and other abnormalities.

Low-Grade Squamous Intraepithelial Lesion (LSIL)

This result indicates infection with HPV. The gynecologist will assess the patient’s condition, and if she appears healthy, she may not require further action aside from another Pap test the following year. If the next Pap test has the same result, the doctor will send the patient for a colposcopy.

High-Grade Intraepithelial Lesion

This result is a more advanced version of a LSIL result and indicates the patient is at a high risk of developing cervical cancer.

Atypical Glandular Cells

This result indicates changes in the glandular cells of the cervix, and the patient will need a colposcopy for further examination.


This is rare, but some women unfortunately develop cervical cancer at a young age. The doctor will refer the patient to an oncologist to begin cancer treatment. This is one of the most important reasons for women to undergo yearly Pap smear tests.

Receiving abnormal results can be alarming, but it’s important for women to understand that an abnormal result does not necessarily indicate cervical cancer. An abnormal result simply means that the cells fall outside the normal range and require closer examination. The chance of receiving a cancer diagnosis from an abnormal Pap test result is quite small.

Ask Questions and Take Charge of Your Health

Patients at Arizona Gynecological Consultants can rest assured that the providers we work with are committed to patient health and safety. Be sure to ask all questions you may have about your Pap smear test or results at your next appointment.